Fabbrica Italiana Sintetici (FIS) engages in the research, development, production and distribution of active pharmaceutical ingredients (APIs) for pharmaceutical companies worldwide. The company handles the custom synthesis of intermediates, advanced intermediates and APIs. It also develops and sells a range of generic APIs including anxiolytics, anticonvulsants, antidepressants, analgesics, anti-inflammatory agents, antibacterials, antifungals, cardiovascular drugs and diuretics. The company was founded in 1957 and is based in Italy, with offices in USA and China. It has production facilities in Montecchio Maggiore and Termoli, Italy, Québec, Canada, and Lugano, Switzerland.