Issue | Pharma's Almanac

Current Issue: Q4 2017

The Role of Innovative Technologies

Also In This Issue

Segregation in the Design of Gene Therapy Manufacturing Facilities

A number of gene therapies are in late-stage clinical trials and expected to reach the market in the next several years. Unlike traditional biologic drugs, gene therapy production can involve the manipulation of replication of viruses. Segregation of manufacturing operations involving viruses is a crucial consideration when designing processes and overall facilities. Significant Market Potential […]

Clinical Trials

Managing the Complexities of Outbound Clinical Drug Distribution

Lack of effective management of the outbound distribution of clinical trial materials can negatively impact study outcomes and ultimately prevent medications from reaching patients in need. With growing numbers of studies across a wider range of locations involving complex protocols and in-home participation, clinical logistics organizations have become important enablers of effective clinical drug distribution. […]

API

Right-First-Time Innovation Approach Drives Continual Investment

Efficient development of optimal routes and manufacturing processes for the production of increasingly complex small molecule APIs requires extensive expertise, advanced equipment and technology, and a right-first-time mentality. Demonstration of these capabilities has resulted in growing demand and a need for continual investment at Alcami’s Germantown, Wisconsin facility. Strong Demand Despite much discussion of the […]

Innovation

Developing Targeted Potassium Channel Openers for CNS-Related Therapeutics

Potassium channels are highly attractive as targets for the development of novel therapeutics. Their diversity and ubiquity, however, combined with a lack of detailed structural and functional insight, pose challenges for the development of selective drug candidates. Combining a multi-platform approach with advanced cell technology is helping to overcome some of these challenges. Advances in […]

API

Achieving Efficient Pharmaceutical Synthesis with Process Intensification

Reducing the time, cost and environmental footprint of manufacturing processes continues to be a major driver of technology development. Process intensification for small molecule API production using flow chemistry technologies gives our clients greater opportunities to implement optimum process solutions on the commercial scale. Why Process Intensification Through Flow Chemistry In the pharmaceutical industry, most […]

Past Issues

View all Past Issues

Clinical Services, Contract Development & Manufacturing

View Issue »

Issue #1 | Volume #2 | Q1 2016

The Breakthrough Issue

View Issue »

Issue #4 | Volume #5 | Q4 2019

The Next-Generation Issue

View Issue »

Issue #2 | Volume #4 | Q2 2018

The Innovation Issue

View Issue »

Issue #4 | Volume #4 | Q4 2018